ABSTRACT
IPHSJ-22-12663(A) Published: 04-April-2022, DOI: 10.36648/ 1108-7366.22.S6.002 Letter to the Editor Despite enormous advances in the treatment and prevention of HIV/AIDS in recent decades, an effective vaccine remains elusive, the vast majority of effective vaccines that have been developed use antibodies to neutralize viral infections, but has found that these do not work with HIV because the virus reproduces and mutates too quickly for the antibodies to be effective. In this way, they activate the signalling cascade of the JAK, NF-kB and IRF3 kinases, which induce the expression mechanisms of Interferon's (IFN) and other pro-inflammatory cytokines. [...]we can say that it is not that HIV vaccines have not been tested, it is that, although they have been tested, the effectiveness has been very low, since in fact five phases 3 vaccine efficacy trials have been carried out so far large-scale campaign against HIV, each costing more than US $100 million.